LIBRIS titelinformation: Contrast-enhanced MRI of human knee cartilage : clinical applications of the novel dGEMRIC technique to study glycosaminoglycan
Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) was first described in 1996 as a nondestructive technique for quantitative measurements of glycosaminoglycan (GAG) concentration in articular cartilage samples.
dGEMRIC using the Look-Locker technique, Carl Siversson et al, Abstract and oral presentation at International Society for Magnetic Resonance in Medicine (ISMRM) meeting 2008, Toronto, Canada, no 5289 B1 inhomogeneity corrected T1-quantification for dGEMRIC using 3D Look- dGEMRIC (delayed Gadolinium Enhanced Magnetic Resonance Image of Cartilage) is a well-established technique for cartilage quality assessment in osteoarthritis at clinical field strengths. The method is robust, but requires injection of contrast agent and a cumbersome examination procedure. The most straightforward application of dGEMRIC or any molecular imaging technique is simply to demonstrate and follow “lesions” in otherwise apparently normal-appearing cartilage. Detection and monitoring of these lesions demonstrate a number of paradigm-changing concepts in the evaluation of cartilage physiology and pathophysiology. To determine the feasibility of using a high resolution isotropic three‐dimensional (3D) fast T1 mapping sequence for delayed gadolinium‐enhanced MRI of cartilage (dGEMRIC) to assess osteoarthritis in dGEMRIC technique uses either a two-dimensional (2D) or 3D spin-echo inversion recovery or saturation recovery sequence with varying inversion time (TI) or repetition time (TR).
Although some techniques such as delayed gadolinium-enhanced MRI of cartilage (dGEMRIC). [19] require the administration of a contrast agent, others such. Aug 19, 2015 The technique of delayed gadolinium- enhanced MRI of cartilage (dGEMRIC) enables the evaluation of early cartilage changes in Delayed gadolinium-enhanced magnetic resonance imaging of cartilage ( dGEMRIC) is sensitive to the glycosaminoglycan content in cartilage that is lost early in gadolinium-enhanced MR imaging of cartilage [dGEMRIC] technique), and T1ρ are among the most widely utilized quantitative MR imaging techniques to What Is the Correlation Among dGEMRIC, T1p, and T2* Quantitative MRI Cartilage Mapping Techniques in Developmental Hip Dysplasia? Melkus, Gerd PhD Herein, we describe the dGEMRIC technique using a new positively charged contrast agent (i.e. dGEMRIC+). Specifically, we report: the synthesis and Methods: dGEMRIC, T2 and native T1 relaxation times of healthy mature human, juvenile porcine technique for reliable assessment of the cartilage PG con-. Nov 10, 2016 Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) allows an dGEMRIC provides a non-invasive method of assessing these effects.
We tested two strategies to reduce metal artifact in dGEMRIC: (1) saturation recovery (SR) instead of inversion recovery (IR) and (2) applying the metal artifact reduction sequence (MARS), in a gadolinium-doped agarose gel phantom and in vivo with titanium hardware. These preliminary results suggest that the dGEMRIC technique may be able to detect change in proteoglycan content in knee cartilage among individuals taking collagen hydrolysate after 24 weeks.
(dGEMRIC) has been shown to be a clinically useful tool for assessing the glycosaminoglycan (GAG) content in cartilage (1–4). Proteoglycans (PGs) are major contrib-utors to the compressive stiffness of cartilage, and are lost in the early stages of osteoarthritis (5). The dGEM-RIC technique measures the T1 relaxation time of car-
trastförstärkt MR (dGEMRIC), där man försöker *Compared to existing techniques for single tunnel ACL reconstruction. operative technique and preliminary. molekylär brosksammansättning, dGEMRIC (delayed Gadolinium-enhanced Parkinson's disease: Measurements with opto-electronic recording technique. dGEMRIC, or delayed gadolinium-enhanced MRI of cartilage is a technique that can be used quantitatively to assess glycosaminoglycan content of cartilage or qualitatively to asses the overall structures of cartilage.
Delayed contrast-enhanced MRI of cartilage (dGEMRIC) is a noninvasive technique to study cartilage glycosaminoglycan (GAG) content in vivo. This study evaluates dGEMRIC in patients with preradiographic degenerative cartilage changes. Seventeen knees in 15 patients (age 35-70) with arthroscopically v …
We have previously shown that. dGEMRIC technique for the hip corre-. Apr 10, 2007 The delayed Gadolinium Enhanced MRI of Cartilage (dGEMRIC) its compressive strength and the dGEMRIC technique uses a negatively Jul 24, 2020 cartilage (dGEMRIC) is a validated MRI technique for detecting early MRI techniques such as T1ρ and T2 mapping have also been shown relaxation mapping of the knee joints of both hind legs. The delayed gadolinium- enhanced MR imaging of cartilage (dGEMRIC) and iGEMRIC techniques were. BACKGROUND: Delayed Gadolinium Enhanced Magnetic Resonance Imaging of Cartilage. (dGEMRIC) was first introduced in 1996 by Bashir et al.
Contrast-enhanced MRI of human knee cartilage-clinical applications of the novel dGEMRIC technique to
T1 - Current knowledge and importance of dGEMRIC techniques in diagnosis of hip joint diseases. AU - Zilkens, Christoph. AU - Tiderius, Carl Johan. AU - Krauspe, Ruediger. AU - Bittersohl, Bernd. PY - 2015. Y1 - 2015
dGEMRIC (delayed Gadolinium Enhanced Magnetic Resonance Image of Cartilage) is a well-established technique for cartilage quality assessment in osteoarthritis at clinical field strengths.
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Specifically, we report: the synthesis and Methods: dGEMRIC, T2 and native T1 relaxation times of healthy mature human, juvenile porcine technique for reliable assessment of the cartilage PG con-. Nov 10, 2016 Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) allows an dGEMRIC provides a non-invasive method of assessing these effects. Methods. In 20 early-stage knee OA patients (KLG I-II), 3D dGEMRIC at 3T was acquired before and 14 weeks after 3 Outcomes of dGEMRIC, however, did not change after Viscosupplementation, indicating no change in cartilage p-values adjusted using Holm's method <0.05 .
AU - Zilkens, Christoph. AU - Tiderius, Carl Johan. AU - Krauspe, Ruediger.
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of a novel surgical technique. (Klinisk medicin Human studies evaluating dGEMRIC as a prognostic Experimental methods and laboratory.
Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) was first described in 1996 as a nondestructive technique for quantitative measurements of glycosaminoglycan (GAG) concentration in articular cartilage samples. (dGEMRIC) is a non-invasive imaging method that measures a surrogate for glycosaminoglycan (GAG) concentration in articular cartilage [1]. GAG is a macromolecule whose con- 2013-07-01 · The non-invasive MR imaging technique called delayed gadolinium enhanced magnetic resonance imaging (MRI) of cartilage (dGEMRIC) can be used to assess the concentration of glycosaminoglycans (GAGs) in the extracellular cartilage matrix 5. 2012-10-01 · Since its first description in 20019, the dGEMRIC technique has been used successfully in orthopaedic and rheumatologic research as well as in clinical practice 10, 11, 12.